Contributors: John Dodam, Sheilah Ann Robertson, Claire Waters, Marieke de Vries

 Species: Feline   |   Classification: Miscellaneous

Introduction

  • Anesthesia means 'without feeling'; includes without pain.
  • Is used to describe the loss of sensation to the entire or any part of the body.
  • Reversible, controlled process of intoxication of the central nervous system (CNS).
  • Aims of anesthesia are to prevent awareness of, and response to pain; to provide restraint, immobility and muscle relaxation without creating a risk to the patient's safety.
    Always discuss the dangers of anesthesia with the owner in advance - this gives the owner time to ask questions. Give information in a written form to avoid misunderstandings.
  • Emphasize some special risks, eg brachycephalic breeds, individual hypersensitivity; intercurrent or pre-existing conditions.
  • Conditions that relate to prognosis, eg diabetes, cardiac dysfunction, renal or hepatic insufficiency, merit special mention.

Indications

  • Restraint Handling cats, eg for diagnostic procedures.
  • To allow surgery that would otherwise cause pain.
  • Legal requirement, eg experimental animals.
  • Capture, handling of wild/zoo animals.

Mechanisms

  • Volatile agents: largely unknown.
  • Some anesthetics act at receptors, enhancing inhibitory pathways (ie propofol Propofol and alfaxalone Alfaxalone.
  • Ketamine Ketamine: multiple binding sites, including NMDA-receptors (antagonist).
  • Some probably disrupt membranes, affecting ion channels/receptors (volatile agents).

Measurement of anesthesia

  • Depth of anesthesia (developed by John Snow), describes the signs and stages of ether anesthesia, based on observations of the patient (viz ocular reflexes, nature of breathing). Correlation of changing physical signs with anesthetic depth of progression.

Stages of ether anesthesia (now historic), based on original observations by Guedel

  • I: induction or voluntary excitement stage.
  • II: involuntary excitement.
  • III: surgical anesthesia: divided into planes 1-3 (or 4), of light to deep surgical anesthesia.
  • IV: overdose  →  excessive central nervous system and cardiovascular function.
  • Assumes linear effect of anesthesia - all anesthetics have same action.
  • Different agents have different effects, eg greater respiratory depression with halothane Halothane than ether.
  • Anesthesia is a dynamic state, dependant on all inputs/overall result on brain.
  • Modern techniques include various drugs affecting autonomic nervous system (balanced anesthesia), making Guedel's classification less reliable.

Modern methods of measurement  

  • Absence of spontaneous movements, jaw tone.
  • Ocular: reflexes and position - presence of palpebral and corneal reflexes.
  • Cardiovascular: heart rate and rhythm, blood pressure, cardiac output etc. Most inhalation agents produce dose dependent depression of cardiovascular function Anesthetic monitoring: overview.
  • Respiratory: rate and tidal volume - minute ventilation, arterial carbon dioxide and oxygen tensions, and hemoglobin saturation. Most inhalation agents produce dose-dependent depression of respiratory function.
  • End-tidal inhalation agent concentration indicates relative depth for inhalation agent of known MAC, (minimum alveolar concentration).
  • Plasma: concentrations of intravenous agents of known pharmacokinetics.
  • Electroencephalogram: brain electrical activity with surface electrodes. Depth of anesthesia/ anesthetic agents used produce characteristic patterns of electrical activity.
Print off the owner factsheet All about anaesthesia All about anaesthesia to give to your client.

Balanced anesthesia

  • Four components of balanced anesthesia:
    • Narcosis.
    • Analgesia.
    • Muscle relaxation.
    • Alteration of autonomic reflexes.
  • Each component can be produced on its own.
  • Balanced anesthesia refers to the use of all four components, each to the degree required for the procedure.
  • Because combined, smaller doses of drugs can be used, minimizing potential side-effects.

Narcosis

  • Drug-induced state of unconsciousness from which the patient cannot be easily aroused.

Analgesia  

  • Analgesia Analgesia: overview.
  • Pain - conscious (cortical) perception of an unpleasant stimuli.
  • Nociception - unconscious perception of a noxious stimulus. It does not require consciousness and can continue abated during general anesthesia in absence of sufficient anti-nociceptive techniques.
  • Reflex suppression - suppression of autonomic reflexes induced by nociceptive stimuli transmitted to noncortical areas of the brain.
  • Analgesic component of balanced anesthesia will prevent pain in conscious animal and autonomic reflexes in unconscious animal.
  • Prevent autonomic tachycardia, hypertension, tachypnea, lacrimation, sweating and reflex muscle activity.
  • Reduces catabolic endocrine and metabolic response of surgery, ie the stress response.
  • Reduces the dose of anesthetic agents required to produce and maintain unconsciousness and therefore their potential side-effects.

Muscle relaxation

Methods

Functions of general muscle relaxation

  • Part of balanced anesthesia.
  • Facilitation of ocular, abdominal and thoracic surgery.
  • Smooth IPPV.
  • Facilitation of esophageal foreign body removal.

Adverse effects of anesthesia

  • Ideal anesthetic produces anesthesia without affecting other body systems:
    • Does not exist.
  • Generally depression of cardiovascular, respiratory, and other systems.
  • 1 in 419 cats die due to anesthesia related complications (overall risk) Anesthesia: complications - overview.

Cardiovascular depression

  • Dose dependent.
  • Myocardial depression, reduces cardiac output.
  • Reduction in peripheral vascular resistance.
  • Hypotension and compromized peripheral perfusion can result.

Respiratory depression

  • Dose dependent.
  • Hypoventilation via central depression of respiratory center and peripheral impedance to lung inflation (chest wall/diaphragm movement restriction):
    • Central depression reduces the sensitivity of the respiratory center to carbon dioxide.
  • Hypercapnia Hypercapnia results - reduced alveolar ventilation.
  • Hypoxemia Hypoxemia - ventilation / perfusion mismatch Ventilation perfusion mismatching and reduced ventilation.
  • Anesthetics depress hypoxic drive to respiration.
  • Adequacy of ventilation linked to degree of intercostal muscle activity.
  • Increase dead space/tidal volume ratio via reduction in tidal volume and increased dead space.
  • Reduced functional residual capacity due to anteriorly displaced end-expiratory diaphragm and reduced serratus ventralis muscle tone.

Renal injury

  • Anesthesia produces a transient decrease in renal blood flow and glomerular filtration rate (GFR) Glomerular filtration rate.
  • Hypoperfusion/hypotension during anesthesia causes a reduction in GFR for the duration of the hypotensive episode.
  • Renal blood flow can compensate to some degree via renal autoregulation which is effective over range of mean arterial pressure of 60-150 mmHg.
  • Ability to compensate can be compromized by drugs administered.
  • NSAIDs Analgesia: NSAID prevent renal autoregulation by inhibiting prostaglandin release Analgesia: overview.
  • Renal failure can result.

Liver pathology

  • Some agents hepatotoxic, eg halothane Halothane. Although reported in humans, this is extremely rare in dogs and cats.
  • Hepatic vasomotor control is minimal and a decrease in hepatic blood flow may be due to a decrease in portal vein or hepatic artery pressure. This in turn can be due to reduced systemic blood pressure, increased hepatic venous pressure or increased splanchnic resistance.
  • Hypoperfusion could exacerbate hepatic injury.

Stress response

  • Stress response caused by any insult, including general anesthesia.
  • Provokes fight or flight reaction.
  • Sympathetic stimulation - cardiovascular stimulation. Initially lifesaving, later can lead to shock if prolonged.
  • Endocrine response - increase catabolic hormones, eg cortisol.
  • Metabolic response - mobilizes energy stores: hyperglycemia, lactic acidemia, lipid store mobilization. May lead to serious protein loss.

Thermoregulation

  • Anesthesia impairs central thermoregulatory control mechanisms.
  • Anesthesia alters heat loss/gain and the ability of the body to compensate for changes.
  • Hypothermia Hypothermia is common.

Methods for general anesthesia

  • General anesthesia can be achieved by intramuscular, subcutaneous, intravenous, intraperitoneal and inhalational routes.
  • Method is animal and procedure dependent.

Ideal anesthetic

  • Independent of metabolism for termination of action and elimination.
  • Allows rapid induction, quick alteration in depth and rapid recovery.
  • Analgesic actions.
  • Does not depress cardiopulmonary function.
  • Non-toxic.
  • Not irritant to any tissue.
  • Inexpensive, stable, non-inflammable, non-explosive.
  • Requires no special equipment for administration.
  • No ideal agent presently available.

Considerations for type of anesthetic

  • Animal species, breed, age.
  • Physical status.
  • Time required for surgery, its type and severity, surgeon's skill.
  • Familiarity with anesthetic technique.
  • Equipment and personnel available.

Intravenous anesthesia

  • Smooth induction of anesthesia Anesthetic induction: overview.
  • Infusion for maintenance Anesthesia: maintenance, but keep as short as possible in cats because of relatively low capacity of glucuronide conjugation.
  • Non-cumulative agents required to avoid prolonged recovery.
  • Advantages of potentially less cardiovascular depression, reduced stress response, no atmospheric pollution, and reduced equipment requirements.
  • Requires IV catheter placement and more difficult to alter anesthetic depth rapidly. Often significant respiratory depression.
  • Renal and hepatic compromise can significantly prolong duration of action.

Inhalation anesthesia

  • Mainstay of general anesthesia.
  • Can be used for induction of anesthesia - dependent on animal and agent used.
  • Ease of use - rapidly able to alter depth of anesthesia.
  • Rapid recovery.
  • Dose dependent cardiorespiratory depression.
  • Atmospheric pollution and occupational hazard to be considered.
  • Some agents cause hepatic and renal toxicity.

Other

  • Route dependent on animal.
  • Intraperitoneal for small animals.
  • Intramuscular for wild animals/uncooperative animals.

Anesthetic records and patient safety checklist

  • The Association of Veterinary Anaesthetists (AVA http://www.ava.eu.com/) has produced patient safety checklists and general anesthesia recording charts for use during the peri-anesthetic period. The RCVS Practice Standards Scheme recommends these resources.
  • Two versions are available:
    • Low ASA status:
      • Suitable for shorter procedures and lower risk patients.
      • Also incorporates the AVA safety checklist.
    • High ASA status:
      • Suitable for higher risk patients and more advanced monitoring.
  • The general anesthesia recording charts and patient safety checklists can be downloaded here: